Publications
A strong foundation of peer reviewed research
R. Bhagar, S. S. Gill, H. Le-Niculescu, C. Yin, K. Roseberry, J. Mullen, M. Schmitz, E. Paul, J. Cooke, C. Tracy, Z. Tracy, A. S. Gettelfinger, D. Battles, M. Yard, G. Sandusky, A. Shekhar, S. M. Kurian, P. Bogdan & A. B. Niculescu. Next-generation precision medicine for suicidality prevention. Translational Psychiatry; 2024 Sep 6; doi: 10.1038/s41398-024-03071-y. doi: 10.1038/s41398-024-03071-y
M. D. Hill, S. S. Gill, H. Le-Niculescu, O. MacKie, R. Bhagar, K. Roseberry, O. K. Murray, H. D. Dainton, S. K. Wolf, A. Shekhar, S. M. Kurian, A. B. Niculescu. Precision medicine for psychotic disorders: objective assessment, risk prediction, and pharmacogenomics. Molecular Psychiatry; 2024 Feb 8; doi: 10.1038/s41380-024-02433-8. doi: 10.1038/s41380-024-02433-8
R. Bhagar, H. Le-Niculescu, K. Roseberry , K. Kosary, C. Daly, A. Ballew, M. Yard, G. E. Sandusky, A. B. Niculescu. Temporal effects on death by suicide: empirical evidence and possible molecular correlates. Discover Mental Health; 2023 April 3; doi: 10.1007/s44192-023-00035-4. 10.1007/s44192-023-00035-4
K. Roseberry, H. Le-Niculescu, D. F. Levey, R. Bhagar, K. Soe, J. Rogers, S. Palkowitz, N. Pina, W. A. Anastasiadis, S. S. Gill, S. M. Kurian, A. Shekhar, and A. B. Niculescu. Towards precision medicine for anxiety disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs. Molecular Psychiatry; 2023 March 7; doi: 10.1038/s41380-023-01998-0. PMID: 36878964
M. Cheng, K. Roseberry, Y. Choi, L. Quast, M. Gaines, G. Sandusky, J. A. Kline, P. Bogdan, A. B. Niculescu. Polyphenic risk score shows robust predictive ability for long-term future suicidality. Discover Mental Health; 2022 June 13; doi: 10.1007/s44192-022-00016-z. PMID: 35722470
Alexander B. Niculescu, Helen Le-Niculescu. Precision medicine in psychiatry: biomarkers to the forefront. Neuropsychopharmacology; 2021 Sept 28; doi: 10.1038/s41386-021-01183-3. PMID: 34584209
Le-Niculescu H, Roseberry K, Gill SS, Levey DF, Phalen PL, Mullen J, Williams A, Bhairo S, Voegtline T, Davis H, Shekhar A, Kurian SM, Niculescu AB. Precision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs. Molecular Psychiatry; 2021 Apr 8; doi: 10.1038/s41380-021-01061-w. [Epub ahead of print]. PMID: 33828235
Niculescu AB, Le-Niculescu H, Roseberry K, Wang S, Hart J, Kaur A, Robertson H, Jones T, Strasburger A, Williams A, Kurian SM, Lamb B, Shekhar A, Lahiri DK, Saykin AJ. Blood biomarkers for memory: toward early detection of risk for Alzheimer disease, pharmacogenomics, and repurposed drugs. Molecular Psychiatry; 2019 Dec 2; doi: 10.1038/s41380-019-0602-2. [Epub ahead of print]. PMID: 31792364
Niculescu AB, Le-Niculescu H. Convergence of recent GWAS data for suicidality with previous blood biomarkers: independent reproducibility using independent methodologies in independent cohorts. Molecular Psychiatry; 2019 August 5; doi: 10.1038/s41380-019-0465-6. [Epub ahead of print]. PMID: 31383925
Le-Niculescu H, Roseberry K, Levey DF, Rogers J, Kosary K, Prabha S, Jones T, Judd S, McCormick MA, Wessel AR, Williams A, Phalen PL, Mamdani F, Sequeira A, Kurian SM, Niculescu AB. Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs. Molecular Psychiatry; 2019 March 12; doi: 10.1038/s41380-019-0370-z. [Epub ahead of print]. PMID: 30862937
Niculescu AB, Le-Niculescu H, Levey DF, Roseberry K, Soe KC, Rogers J, Khan F, Jones T, Judd S, McCormick MA, Wessel AR, Wiliams A, Kurian SM, White FA. Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs. Molecular Psychiatry; 2019 Feb 12; doi: 10.1038/s41380-018-0345-5. [Epub ahead of print]. PMID: 30755720
Brucker KM, Duggan C Roseberry K, Le-Niculescu H, *Niculescu AB, *Kline JA. Assessing Risk of Future Suicidality in Emergency Department Patients. Academic Emergency Medicine; 2018 Oct 30; doi: 10.1111/acem.13562. [Epub ahead of print]. PMID: 30375082
Niculescu AB, Le-Niculescu H, Levey DF, Phalen PL, Dainton HL, Roseberry K, Niculescu EM, Niezer JO, Williams A, Graham DL, Jones TJ, Venugopal V, Ballew A, Yard M, Gelbart T, Kurian SM, Shekhar A, Schork NJ, Sandusky GE, Salomon DR. Precision medicine for suicidality: from universality to subtypes and personalization. Molecular Psychiatry; 2017 Sep;22(9):1250-1273; doi: 10.1038/mp.2017.128. Epub 2017 Aug 151 . PMID: 28809398
Niculescu AB, Le-Niculescu H. Dissecting Suicidality Using a Combined Genomic and Clinical Approach. Neuropsychopharmacology; 2017 42 360; doi:10.1038/npp.2016.228. PMID: 27909331
Rangaraju S, Levey DF, Nho N, Jain N, Andrews KD, Le-Niculescu H, Salomon DR, Saykin AJ, Petrascheck M, and Niculescu AB. Mood, Stress and Longevity: Convergence on ANK3. Molecular Psychiatry; 2016 Aug;21(8):1037-49; doi: 10.1038/mp.2016.65. Epub 2016 May 24. PMID: 27217151
Levey DF, Niculescu EM, Le-Niculescu H, Dainton HD, Phalen PL, Ladd TB, Weber H, Belanger E, Graham DL, Khan FN, Vanipenta NP, Stage EC, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR, Niculescu AB. Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment. Molecular Psychiatry; 2016 Jun;21(6):768-85; doi: 10.1038/mp.2016.31. Epub 2016 Apr 5. PMID: 27046645
Niculescu AB. A brief proposal for improving clinical trials. Molecular Psychiatry; 2016 Jun;21(6):736-7; doi: 10.1038/mp.2016.42. Epub 2016 Mar 29. PMID: 27021813
Rangaraju S, Solis GM, Thompson RC, Gomez-Amaro RL, Kurian L, Encalada SE, Niculescu AB, Salomon DR, Petrascheck M. Elife. Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality. eLife; 2015 Dec 1;4; pii: e08833. doi: 10.7554 . PMID: 26623667
Niculescu AB, Levey DF, Phalen PL, Le-Niculescu H, Dainton HD ,Jain N, Belanger E, James A, George S, Weber H, Graham DL, Schweitzer R, Ladd TB, Learman R, Niculescu EM, Vanipenta NP, Khan FN, Mullen J, Shankar G, Cook S, Humbert C, Ballew A, Yard M, Gelbart T, Shekhar A, Schork NJ, Kurian SM, Sandusky GE, Salomon DR. Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach. Molecular Psychiatry; 2015 20: 1266–1285; doi:10.1038/mp.2015.112; Epub August 18 . PMID: 26283638
Rangaraju S, Solis GM, Andersson SI, Gomez-Amaro RL, Kardakaris R, Broaddus CD, Niculescu AB, Petrascheck M. Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non-cell-autonomous stress response. Aging Cell; 2015 Dec;14(6):971-81; doi: 10.1111/acel.12379. Epub 2015 Aug 8 . PMID: 26255886
Niculescu AB, Levey DF, Le-Niculescu H, Niculescu E, Kurian SM, Salomon, D. Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions. Molecular Psychiatry; 2015 Mar;20(3):286-8; doi: 10.1038/mp.2014.180. Epub 2015 Jan 13. PMID: 25582618
Levey DF., H. Le-Niculescu, J. Frank, M. Ayalew, N. Jain, B. Kirlin, R. Learman, E. Winiger, Z.A. Rodd, A. Shekhar, N. J. Schork, F, Kiefe, N. Wodarz, B. Müller-Myhsok, N. Dahmer, GESGA Consortium, M. Nöthen, R. Sherva, L. Farrer, A. H. Smith, H. Kranzler, M. Rietschel, J. Gelernter, A. B. Niculescu. Genetic Risk Prediction and Neurobiological Understanding of Alcoholism. Translational Psychiatry; 2014 May 20;4:e391; doi: 10.1038/tp.2014.29. 2014 Epub May 20. PMID: 24844177
Niculescu AB. DISCovery in psychiatric genetics. Molecular Psychiatry; 2014 Feb;19(2):145; doi: 10.1038/mp.2013.176. Epub 2013 Dec 17. PMID: 24342993
Niculescu AB. Convergent functional genomics of stem cell-derived cells. Translational Psychiatry; 2013 Sep 10;3:e305; doi: 10.1038/tp.2013.78. PMID: 24022510
Le-Niculescu H, Levey D, Ayalew M, Palmer L, Gavrin LM, Jain N, Winiger E, Bhosrekar S, Shankar G, Radel M, Bellanger E, Duckworth H, Olesek K, Vergo J, Schweitzer R, Yard M, Ballew A, Shekhar A, Sandusky GE, Schork NJ, Kurian SM, Salomon DR, Niculescu AB. Discovery and validation of blood biomarkers for suicidality. Molecular Psychiatry; 2013 Dec;18(12):1249-64; doi: 10.1038/mp.2013.95. Epub 2013 Aug 20. PMID: 23958961
Niculescu AB. Convergent Functional Genomics of Psychiatric Disorders. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics; 2013 Oct;162B(7):587-94; doi: 10.1002/ajmg.b.32163. 2013 Epub May 31..
Ayalew M, Le-Niculescu H, Levey D, Jain N, Changala B, Patel SD, Winiger E, Breier A, Shekhar A, Amdur R, Koller D, Nurnberger JI, Corvin A, Geyer M, Tsuang MT, Salomon DR, Schork NJ, Fanous A, O’Donovan M, Niculescu AB. Convergent Functional Genomics of Schizophrenia: From Comprehensive Understanding to Genetic Risk Prediction. Molecular Psychiatry; 2012 Sep;17(9):887-905; doi: 10.1038/mp.2012.37. Epub 2012 May 15.
Le-Niculescu H, Balaraman Y, Patel SD, Ayalew M , Gupta J, Kuczenski R, Shekhar A, Schork N, Geyer MA and Niculescu AB. Convergent functional genomics of anxiety disorders: translational identification of genes, biomarkers, pathways and mechanisms. Translational Psychiatry; 2011. Epub 2011 May 24.; .
Le-Niculescu H, Case NJ, Hulvershorn L, Patel SD , Bowker D, Gupta J, Bell R, Edenberg HJ , Tsuang MT, Kuczenski R, Geyer MA, Rodd Z, Niculescu AB. Convergent Functional Genomic Studies of Omega-3 Fatty Acids in Stress Reactivity, Bipolar Disorder and Alcoholism. Translational Psychiatry; 2011. Epub 2011 April 26.; .
Kurian SM, Le-Niculescu H, Patel SD, Bertram D, Davis J, Dike C, Yehyawi N, Lysaker P, Dustin J, Caligiuri M, Lohr J, Lahiri DK, Nurnberger Jr JI, Faraone SV, Geyer MA, Tsuang MT, Schork NJ, Salomon DR and Niculescu AB. Identification of blood biomarkers for psychosis using convergent functional genomics. Molecular Psychiatry; 2011 February; 16, 37–58. Epub 2009 Nov 24..
Patel SD, Le-Niculescu H, Koller DL, Green SD, Lahiri DK, McMahon F, Nurnberger JI, Niculescu AB. Coming to Grips With Complex Disorders: Genetic Risk Prediction in Bipolar Disorder Using Panels of Genes Identified Through Convergent Functional Genomics. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics); 2010. Jun 5; 153B(4):850-77. Epub April 9.. PMID: 20468069
Niculescu AB, Le-Niculescu H. The P-Value Illusion: How to Improve (Psychiatric) Genetic Studies.. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics); 2010. Jun 5; 153B(4):847-9.
Niculescu AB, Hulvershorn L. Toward Early, Personalized, Rational Polypharmacy In Psychiatry: A Tri-Dimensional Approach. Psychopharm Review; 2010; 45(2): 9-16.
Niculescu AB, Le-Niculescu H. Convergent Functional Genomics: What We Have Learned and Can Learn About Genes, Pathways, and Mechanisms. Neuropsychopharmacology; 2010 Jan; 35(1):355-6.
Le-Niculescu H, Patel SD, Bhat M, Kuczenski R, Faraone SV, Tsuang MT, McMahon FJ, Schork NJ, Nurnberger Jr JI, and Niculescu AB. Convergent Functional Genomics of Genome-Wide Association Data for Bipolar Disorder: Comprehensive Identification of Candidate Genes, Pathways and Mechanisms. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics); 2009 Mar 5; 150B(2):155-181.
Le-Niculescu H, Kurian SM, Yehyawi N, Dike C, Patel SD, Edenberg HJ, Tsuang MT, Salomon DR, Nurnberger Jr JI, Niculescu AB. Identifying Blood Biomarkers For Mood Disorders Using Convergent Functional Genomics. Molecular Psychiatry; 2009 Feb; 14(2):156-74. Epub 2008 Feb 26..